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KMID : 0617219900010010071
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Duksung Bulletin Phamaceutical Sciences
1990 Volume.1 No. 1 p.71 ~ p.81
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Studies on Detoxicating Effects of Several Medicinal Plant Extracts to the Polychlorinated Biophenyls Toxicity
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Abstract
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The effect of the water extracts and ethanol extracts from picrorrhiza kurroa, Gentiana scabra and Lycium chinense on the toxicity of polychlorinated biphenyls (PCBs) were examined and following results were obtained.
1. In the PCBs control group, the body weights were decreased while the weight of liver was increased in comparison with that of normal control group. However, by the administration of these extracts, PCBs intoxicated rats showed the increase in body weight but did not show marked recovery of liver weight.
2. By the administration of these extracts, the hematological parameters of red blood cell and white blood cell, hemoglobin content and hematocrit value which were decreased by the administration of PCBs were shown to be increased. Among these extracts, the extracts of Lycium chinense were especially effective.
3. Cholesterol and total lipids levels in serum were significantly increased in the group fed PCBs. These extracts ameliorated the elevated levels but the recovery was not completed.
4. The activities of s-GOT, s-GPT and alkaline phosphatase were significantly stimulated by PCBs and their stimulation was inhibited by the adminstration of these extracts. Furthermore, the extracts of Picrorrhiza kurroa showed the normalizing tendency in s-GOT, s-GPT and alkaline phosphatase.
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